Circhomer1
WebCircHomer1, is a neuronal-enriched circRNA, derived from exons 2 and 5 of the precursor of the Homer1B mRNA isoform and abundantly expressed in adult frontal cortex. Previous data have indicated that circHomer1 is significantly altered in postmortem brains of SCZ/BD patients and circHomer1 KD is associated with cognitive disturbances. In my ... WebDec 7, 2024 · Lastly, we demonstrate that circHomer1 is an experience-dependent circRNA that is significantly altered during chance reversal learning and that variability in its baseline expression within the OFC is significantly inversely correlated to behavioral performance during chance reversal learning. Taken together our data provide novel mechanistic ...
Circhomer1
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WebWe demonstrate that circHomer1 is an experience-dependent circRNA that is significantly altered during chance reversal learning and that variability in its baseline expression is significantly ... http://kns55.zh.eastview.com/kcms/detail/detailall.aspx?filename=1020139458.nh&dbcode=CMFD&dbname=CMFD2024
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WebJan 18, 2024 · Importantly, double circHomer1 and Homer1b in vivo co-KD results in a complete rescue in circHomer1-associated alterations in both chance reversal learning and synaptic gene expression. Lastly, we uncover an RNA-binding protein that can directly bind to circHomer1 and promote its biogenesis. Taken together, our data provide … WebCircHOMER1 was highly expressed in HG-induced HMCs and DN patients. Downregulation of circHOMER1 suppressed oxidative stress, inflammation and ECM deposition in HMCs induced by HG. In terms of mechanism, circHOMER1 could sponge miR-137 to regulate SOX6. Function assays showed that miR-137 inhibitor or SOX6 overexpression revoked …
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Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 the park roanoke virginiaWebCircHOMER1 has been identified to be associated with the pathogenesis of CRC. 18 Zhao et al revealed that miR-138-5p functioned as a tumor suppressor to inhibit CRC cell growth via decreasing PD-L1. 30 In this study, we demonstrated, lidocaine-induced cell viability loss, apoptosis induction and aerobic glycolysis suppression in CRC could be ... shuttle xh610vWebFeb 17, 2024 · Figure 1. Expression of circhomer1, Eif4a3, and H19 in the male and female adult frontal cortex and hippocampus.(A,B) Mean ± SEM circHomer1 levels (normalized to 18S rRNA and further normalized to the mean of Control male SAC circHomer1 levels) in adult male and female (fem) PAE and SAC adult frontal cortex (A) and hippocampus … the park roomWebDec 7, 2024 · In vivo knockdown of circHomer1 in the mouse frontal cortex alters synaptic gene expression and disrupts cognitive flexibility. Moreover, circHomer1 can bind to an RNA-binding protein that can increase its synaptic localization. Lastly, ongoing work is aimed at understanding how circHomer1 can affect synaptic gene expression and … the park room nycWebJul 27, 2024 · Inhibition of circHomer1 expression indeed alleviated METH-induced neurotoxicity, with lower apoptosis rate via flow cytometry and cleaved Caspase3 protein level. Furthermore, we speculated that Bbc3 functioned as a target of circHomer1 based on computational algorithm, and knockdown of circHomer1 actually reduced Bbc3 … shuttle xh81vWebDec 1, 2024 · Importantly, double circHomer1 and Homer1b in vivo co-KD results in a complete rescue in circHomer1-associated alterations in both chance reversal learning and synaptic gene expression. Lastly, we uncover an RNA-binding protein that can directly bind to circHomer1 and promote its biogenesis. Taken together, our data provide … the park rooley lane bradfordthe park room grosvenor house