Ctcf and ctcfl in cancer

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August undefined, 2024

WebMay 11, 2024 · Ubiquitously expressed CTCF is involved in numerous cellular functions, such as organizing chromatin into TAD structures. In contrast, its paralog, CTCFL, is … WebFeb 7, 2024 · The oncogene CTCFL (BORIS), the paralog of CTCF, is a transcriptional factor highly expressed in ovarian cancer (but in rarely any other tissue in females) with cancer-specific characteristics and ...

PRAME and CTCFL-reactive TCRs for the treatment of …

WebApr 13, 2024 · MYC reshapes CTCF-mediated chromatin architecture in prostate cancer. April 13, 2024. MYC is a well characterized oncogenic transcription factor in prostate … WebApr 22, 2024 · Search life-sciences literature (41,693,946 articles, preprints and more) Search smart books ten little indians

CTCFL — Early Detection Research Network

WebNov 2, 2024 · However, in cancer, CTCF is substituted by CTCFL/BORIS, depicted as a blue circle, shutting down the transcription of these tumor suppressor genes through activation of anti-sense transcripts. The … WebApr 1, 2024 · In this regard, BORIS (CTCFL), a CTCF paralog, is a promising cancer biomarker that is overexpressed and controls transcription in several cancer types, … WebApr 10, 2024 · Pan-cancer bioinformatics analysis showed that the expression of DTL was correlated with the prognosis, immunotherapy, and clinical indexes in various cancers. ... NRF1, E2F4, STA T3, CTCF, CTCFL ... smart books logo

Targeting CTCFL/BORIS for the immunotherapy of …

WebAug 31, 2016 · A common aberration in cancer is the activation of germline-specific proteins. The DNA-binding proteins among them could generate novel chromatin states, not found in normal cells. The germline-specific transcription factor BORIS/CTCFL, a paralog of chromatin architecture protein CTCF, is often erroneously activated in cancers and … Web2 days ago · Cancer remains the main cause of human death worldwide, and most cancers still lack effective prevention and treatment means [].In recent years, immune checkpoint (ICP) blockade and targeted drug therapy have greatly improved the therapeutic effect of cancer patients, but there are still problems such as limited patient benefit and difficulty … smart books franchiseWebIn ovarian cancer CTCFL expression indeed correlates with advanced stage and decreased survival . In other tumor types CTCFL expression has also been detected, although expression data have been contradictory . According to the TCGA data, CTCFL is mainly expressed in ovarian cancer (Supplementary Figure 2). smart books victoria bc

"WebOct 5, 2024 · BORIS (CTCFL) is a DNA binding protein which is involved in tumorigenesis. Although, there are different opinions on the level of gene expression and function of BORIS in normal and cancer tissues, the results of many studies have classified BORIS as a protein belonging to cancer/testis (CT) genes, which are identified as a group of genes … " - Ctcf and ctcfl in cancer

Ctcf and ctcfl in cancer

WebNov 2, 2024 · However, in cancer, CTCF is substituted by CTCFL/BORIS, depicted as a blue circle, shutting down the transcription of these tumor suppressor genes through activation of anti-sense transcripts. The … WebMar 20, 2024 · As CTCF is a significantly mutated gene in endometrial cancer, we sequenced CTCF in five endometrial cancer cell lines and identified four mutations (Figures 1a and c).

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WebMar 30, 2024 · Here, we show that MYC reshapes the chromatin architecture of prostate cancer (PCa) cells through interacting with CTCF protein. By defining H3K27ac, AR and CTCF HiChIP profiles and CRISPR ... WebCancer remains the main cause of human death worldwide, and most cancers still lack effective prevention and treatment means ... that DTL interacted with arsenic trioxide, aflatoxin b1, MLN7243 and palmitic acid. In addition, NRF1, E2F4, STAT3, CTCF, CTCFL and E2F1 were predicted to be the interacting targets. Hsa-miR-330-3p, hsa-miR ...

WebMar 3, 2024 · An expanding literature describes a cancer-associated role for BRD8 (reviewed in (Fujisawa and Filippakopoulos, ... Since BRD8 is not predicted to bind directly to DNA, an association with CTCF/CTCFL could be an effective route to achieving chromatin proximity (Pena-Hernandez, Marques, Hilmi et al., 2015). To further explore … http://www.cancerindex.org/geneweb/CTCFL.htm

WebCCCTC-binding factor ( CTCF ), an 11- zinc finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive … WebApr 1, 2024 · In this regard, BORIS (CTCFL), a CTCF paralog, is a promising cancer biomarker that is overexpressed and controls transcription in several cancer types, mainly in OC.

WebBACKGROUND: BORIS/CTCFL, a paralog of CTCF and member of the cancer-testicular antigen family, is abnormally activated in multiple cancers. OBJECTIVE: We investigated …

WebApr 4, 2024 · CTCF provided by HGNC Official Full Name CCCTC-binding factor provided by HGNC Primary source HGNC:HGNC:13723 ... LncRNA PCGEM1 promotes colorectal cancer cell proliferation and migration in positive feedback loop through PCGEM1/miR-433-3p/CTCF axis. ... CTCFL paralog. NCBI Reference Sequences (RefSeq) Go to the top of … hill rom mobility scaleWebCTCFL; Zinc finger protein CTCF-T; cancer/testis antigen 27; dJ579F20.2; Description CTCFL, a testis-specific DNA binding protein containing 11 C2H2-type zinc fingers, … hill rom navicare manualWebResearch to identify CTCFL as a biomarker for specific cancer types and for therapeutical approaches has been followed up . With the advent of next-generation-sequencing many advances in the field of DNA binding factors have been made. ... CTCF/CTCFL co-bound and CTCF or CTCFL stand-alone sites) and the average CTCF site as reference were ... hill rom navicare partsWebCTCFL is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes. ... BORIS like protein; BORIS-like protein; Brother of the regulator of imprinted sites; Cancer/testis antigen 27; CCCTC-binding factor; CCCTC-binding factor (zinc finger protein)-like; CCCTC-binding factor like; CT27; CTCF paralog; CTCF T; … smart books royal oak bcWebCTCF-mediated enhancer blocking is conserved from Drosophila to man (Moon et al. 2005) Antisense transcription of triplet repeats is constrained by CTCF (Cho et al. 2005) Boundaries between X inactivation and escape of inactivation bind CTCF (Filippova et al. 2005) CTCF antagonizes with CTCFL at the cancer testis gene MAGE-A1 (Vatolin et al. … smart bookshelfWebIn ovarian cancer CTCFL expression indeed correlates with advanced stage and decreased survival . In other tumor types CTCFL expression has also been detected, although … smart bookxWebJun 23, 2024 · The past and present efforts to combine CTCF studies with CTCFL/BORIS research are designed to emphasize Normal and … hill rom monarch vest colors