WebIRF8 is a transcriptional regulator that is essential for the differentiation and function of monocytes and macrophages and thus may be involved in the regulation of macrophage … WebInterferon regulatory factor 8 (Irf8), also known as interferon consensus sequence-binding protein, is a component of the Irf transcription factor family. Irf8 is differentially expressed …
018298 - Irf8[-] Strain Details - The Jackson Laboratory
WebProduct Specific Information. Description: The V3GYWCH monoclonal antibody reacts with human and mouse interferon regulatory factor 8 (IRF8; ICSBP). IRF8 is a 50 kDa transcription factor that plays a critical role in the development of dendritic cells (DC). Specifically, IRF8 is essential in the development and differentiation of plasmacytoid ... WebFigure Legend Snippet: Upregulation of downstream targets of ERK pathway. A. Western Blot analysis of protein extract from normal appearing mucosa obtained from small intestines tissues from LSL-K-RasG12D and Villin-Cre/LSL-K-RasG12D mice. 10 ug of total protein extracts from LSL-K-RasG12D and Villin-Cre/LSL-K-RasG12D were analyzed by Western … im byob
Down-regulation of Irf8 by Lyz2-cre/loxP accelerates
WebThe Irf8 floxed targeted mutated mouse strain can be used to selectively ablate expression of IRF8 in any cell type in which a Cre recombinase gene is activated. This will permit the... WebAug 1, 2024 · Finally, we assessed skin fibrosis in myeloid cell–specific IRF8 conditional knockout (Irf8 flox /flox; Lyz2 Cre/+) mice and found upregulated mRNA levels of extracellular matrix components and increased bleomycin-induced skin fibrosis. In conclusion, altered IRF8 regulation in monocytes and macrophages may be involved in … WebIrf8 cKO mice were generated by crossing Irf8 fl/fl mice with Csf1r cre mice, a monocyte/macrophage targeting Cre driver mice. ... Monocyte Subsets with High Osteoclastogenic Potential... list of job\u0027s afflictions