Barasertib-hqpa
WebBarasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor with an IC 50 of 0.37 nM in a cell-free assay. Barasertib-HQPA (AZD2811) induces growth arrest and … WebAZD1152-HQPA (Barasertib) is a highly potent and selective inhibitor of Aurora with Ki values of 0.36 and 1369 nM for Aurora B and Aurora A respectively.Consistent with …
Barasertib-hqpa
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WebBarasertib, previously known as AZD1152-hydroxyquinazoline pyrazol anilide (HQPA), is a potent aurora kinase inhibitor, which is resulted from rapid phosphatase-mediated … WebSep 1, 2012 · The PK profile of barasertib is similar to previous studies using the same dosing regimen in patients with AML. The majority of barasertib-hQPA clearance occurred via hepatic metabolic routes.
WebIn one embodiment the anticancer therapy employs an aurora kinase inhibitor. Examples of aurora kinase inhibitors Include: Aurora A Inhibitor I, VX-680, AZD1152-HQPA (Barasertib), SNS- 314 Mesylate, PHA-680632, ZM-447439, CCT129202 and Hesperadin. WebSystemic exposure to barasertib-hQPA, the more active moiety to which barasertib is converted, was observed by 1 and 6 h into the 2-h and continuous infusion ... barasertib …
WebAZD-1152 HQPA, also known as AZD-2811, is a potent and selective Aurora B inhibitor (IC50 of 0.37 nM versus 1368 nM for Aurora B and A kinases, respectively), serine/ … WebJun 16, 2011 · Barasertib-hQPA is a highly selective inhibitor of aurora-B kinase that has shown tumouricidal activity against a range tumour cell lines including those of leukaemic AML origin. Methods Effect of barasertib-hQPA on the pHH3 biomarker and cell viability was measured in a panel of leukaemic cell lines and 37 primary AML samples by flow …
WebAZD1152-HQPA is a highly potent and selective inhibitor of Aurora B (Ki, 0.36nmol/L) compared with Aurora A (Ki, 1.369nmol/L) and has a high specificity versus a panel of 50 …
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