Circular rnas in human cancer

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August undefined, 2024

WebMay 11, 2024 · circRNAs can have different functions. Among these, the miRNA sponging is the best-characterized role. circRNAs are widely expressed in human tissues and their expression is highly tissue-specific. circRNAs are involved in many human diseases, including cancer and neurodegenerative disorders. WebPubMed Central (PMC)

Identification of Key Genes and Circular RNAs in Human Gastric Cancer

WebFeb 20, 2024 · The single-stranded closed RNA molecules (circRNA) are a new class of non-coding RNAs, originating from back-splicing of pre-mRNAs, that have several biological functions in normal cells including the ability to act as sponges to efficiently subtract microRNAs and proteins (32). scrap timber glasgow

Mechanisms of circular RNA degradation Communications Biology

WebMay 7, 2024 · CircRNAs demonstrate diverse expression patterns in various mammalian cells, including brain, heart, lung, neuron, and tumor cell lines, and play an important biological role in the development and progress of diseases such as cancer.43,44 For example, circRNAs can act as miRNA sponges such as CDR1 (cerebral degeneration … WebBreast cancer is a frequent disease for which the discovery of markers that enable early detection or prognostic assessment remains challenging. Circular RNAs (circRNAs) are single-stranded structures in closed loops that are produced by backsplicing. CircRNA and messenger RNA (mRNA) are generated co-transcriptionally, and backsplicing and linear … WebFeb 15, 2024 · Despite being at an early stage, recent works have shown that circular RNAs play key roles in human cancers. The translation of circRNAs will open a hidden … scrap timber collection

The emerging roles and potential applications of circular RNAs in ...

Circular RNAs-mediated angiogenesis in human …

WebNational Center for Biotechnology Information WebCircular RNAs (circRNAs) are an intriguing class of RNA due to their covalently closed structure, high stability, and implicated roles in gene regulation. Here, we used an exome capture RNA sequencing protocol to detect and characterize circRNAs across >2,000 cancer samples. When compared against Ribo-Zero and RNase R, capture sequencing ... scrap timah solderWebAug 13, 2024 · CircRNAs are a class of noncoding RNA species with a circular configuration that is formed by either typical spliceosome-mediated or lariat-type splicing. The expression of circRNAs is usually abnormal in many cancers. Several circRNAs have been demonstrated to play important roles in carcinogenesis. scrap ticket form

"WebApr 18, 2024 · Circular RNAs (circRNAs) are a class of RNA molecules with closed loops and high stability. CircRNAs are abundantly expressed in eukaryotic organisms and … " - Circular rnas in human cancer

Circular rnas in human cancer

WebSep 2, 2024 · Circular RNAs (circRNAs) comprise a group of non-coding RNAs in multicellular organisms, which are identified with characteristic circular structure. CircRNAs have been found with substantial functions in regulating gene… View on Springer ncbi.nlm.nih.gov Save to Library Create Alert Cite 6 Citations Citation Type More Filters WebFeb 3, 2024 · Circular RNAs (circRNAs) are single-stranded circularized RNA molecules produced from back-splicing. Accumulating evidence has shown that circRNA dysregulations are involved in a variety of human disorders, including viral infection ( 1 ), cardiac fibrosis ( 2 ), diabetes ( 3 ), and cancer ( 4 ).

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WebMay 9, 2024 · Maass et al. presented a map of human circular RNAs in clinically relevant tissues, including the placenta. A total of 227 circRNAs were found to be significantly up-regulated and 255 circRNAs significantly down-regulated in gestational diabetes mellitus (GDM) and play potential roles in its pathogenesis [ 204 ]. WebAug 26, 2024 · However, there is no characterization of circular RNAs (circRNAs) in a large number of cancer cell lines. Methods Here, we apply four circRNA identification algorithms to heuristically characterize the expression landscape of circRNAs across ~ 1000 human cancer cell lines from CCLE polyA-enriched RNA-seq data.

WebCircular RNAs (circRNAs) as small non-coding RNAs with cell, tissue, or organ-specific expression accomplish a broad array of functions in physiological and pathological processes such as cancer development. Angiogenesis, a complicated multistep process driving a formation of new blood vessels, speeds up tumor progression by supplying … WebApr 15, 2015 · Circular RNAs (circRNAs) are a special class of endogenous RNAs featuring stable structure and high tissue-specific expression [1]. They are common in mammalian cells and regulate gene expression at the transcriptional or post-transcriptional level by interacting with microRNAs (miRNAs) or other molecules [2].

WebAug 13, 2024 · CircRNAs are a class of noncoding RNA species with a circular configuration that is formed by either typical spliceosome-mediated or lariat-type splicing. The expression of circRNAs is usually... WebJul 15, 2024 · Circular RNAs (circRNAs), which are a class of endogenous RNA with covalently closed loops, play important roles in epigenetic regulation of gene expression at both the transcriptional and post-transcriptional level. Accumulating evidence demonstrated that numerous circRNAs were abnormally expressed in tumors and their dysregulation …

WebcircRNAs-mediated angiogenesis in human cancers. Circular RNAs CircRNAs are a novel and evolutionarily conserved class of ncRNAs generated by an alternative RNA splicing approach termed “back-splicing” [23]. ... of human cancer by targeting specic downstream targets (Table 1). The role of circRNA-mediated angiogenesis in various types of ...

WebJan 18, 2024 · Circular RNAs (circRNAs) are a class of endogenous single-stranded covalently closed RNAs, primarily produced from pre-mRNAs via non-canonical … scrap those red rocket pump armsWebJul 15, 2024 · Circular RNAs (circRNAs), which are a class of endogenous RNA with covalently closed loops, play important roles in epigenetic regulation of gene expression … scrap threadsWebOct 9, 2024 · Circular RNA (circRNA) is a novel member of the noncoding cancer genome with distinct properties and diverse cellular functions, which is being explored at a … scrap tin sourcesWebJan 31, 2024 · CircRNAs are a novel type of RNAs. With the newly developed technology of next-generation sequencing (NGS), especially RNA-seq technology, over 30,000 … scrap timber near meWebJan 12, 2024 · CircRNAs are circular, noncoding RNAs that arise through back-splicing of precursor mRNAs [ 7 ]. They can “sponge” microRNAs [ 8, 9] or interact with RNA-binding proteins [ 10] to regulate cell... scrap thisWebDec 9, 2024 · Circular RNAs (CircRNAs) are a class of noncoding RNAs formed by backsplicing during cotranscriptional and posttranscriptional processes, and they widely exist in various organisms. CircRNAs... scrap tipping trailerWebHere, we systematically characterize circRNAs expression profile in 935 cancer cell lines across 22 cancer lineages from Cancer Cell line Encyclopedia (CCLE), and analyzed the circRNAs biogenesis regulators, effect of circRNAs on drug response and association between circRNAs with mRNA, protein and mutation, and predicted RNA regulatory … scrap tire management is primarily regulated