Dynein intermediate chain binding

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August undefined, 2024

WebDec 8, 2024 · Dynein_heavy; Dynein heavy chain and region D6 of dynein motor pfam08393 Location: 763 → 1162 DHC_N2; Dynein heavy chain, N-terminal region 2 pfam12777 Location: 2586 → 2933 MT; Microtubule-binding stalk of dynein motor pfam12781 Location: 2962 → 3178 AAA_9; ATP-binding dynein motor region D5 … WebCytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component …

DYNLT (Tctex1) forms a tripartite complex with Dynein Intermediate ...

WebFeb 26, 2007 · The largest subunit of dynactin, p150(glued), binds the dynein intermediate chain and has an N-terminal microtubule-binding domain. To examine the role of microtubule binding by p150(glued), we replaced the wild-type p150(glued) in Drosophila melanogaster S2 cells with mutant DeltaN-p150 lacking residues 1-200, which is unable … WebMar 29, 2024 · Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the … is doxycycline a blood thinner

201625 - Gene ResultDNAH12 dynein axonemal heavy chain 12

WebNov 23, 2024 · Central to the function of this motor protein complex is dynein intermediate chain (IC), which binds the three dimeric dynein light chains at multivalent sites, and dynactin p150 Glued and nuclear distribution protein (NudE) at overlapping sites of its intrinsically disordered N-terminal domain. The disorder in IC has hindered cryo-electron ... WebWe show that human dynein light intermediate chain (DLIC) binds the N-terminal RH1 domain of JIP3, its paralog JIP4, and the lysosomal adaptor RILP. A point mutation in RH1 abrogates DLIC binding without perturbing the interaction between JIP3’s RH1 domain and kinesin heavy chain. WebLC4/Ca+2 binding: Related protein: ... Indeed, a direct interaction has been shown between dynein intermediate chain and KLCs. The interaction of these proteins may reflect a … is doxy sulfa

140735 - Gene ResultDYNLL2 dynein light chain LC8-type 2

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WebMay 15, 2015 · The intermediate chains (DYNC1I) play a key scaffold role in the dynein complex. In neurons, dynein complexes with different intermediate chain isoforms have … WebEnter the email address you signed up with and we'll email you a reset link. ryan conlonWebHomodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. ryan conlin

"WebDynein axonemal heavy chain 5 is a protein that in humans is encoded by the DNAH5 gene. [5] [6] [7] DNAH5 is a protein-coding gene. 1 It provides the instructions for synthesizing a protein that belongs to a microtubule-associated protein complex made of heavy, light and intermediate chains. 2 DNAH5 is responsible for making the heavy … " - Dynein intermediate chain binding

Dynein intermediate chain binding

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WebCytoplasmic dynein and dynactin are megadalton-sized multisubunit molecules that function together as a cytoskeletal motor. In the present study, we explore the mechanism of dynein-dynactin binding in vitro and then extend our findings to an in vivo context. Solution binding assays were used to define binding domains in the dynein intermediate chain (IC) and … WebMay 15, 2024 · The remarkable ability of dynein to interact with a diverse cargo spectrum stems from its tightly regulated recruitment of cargo-specific adaptor proteins, which …

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Web3.5.2 Dynein. Dynein is a large macromolecular complex with a molecular weight of approximately 1.2 MDa. It is composed of heavy intermediate, light intermediate, and light chains. The heavy chains contain the motor domains with six AAA ATPase domains and an MT-binding stalk ( Fig. 2.3; Oiwa and Sakakibara, 2005 ). WebFeb 12, 2015 · The dynein tail consists of two copies of the dynein heavy chain (DHC), intermediate chain (DIC2), light intermediate chain (DLIC1), and light chains (Roadblock, Tctex, and LC8). ... The requirement to form a three-way complex would reduce the chance of stochastic binding of dynein to its cargos. The shoulder coats three sides of the …

WebAlready active dynein does not need ADP-binding (Hayashi and Shingyoji, 2008). Some ODA mutants of Chlamydomonas decrease beating under viscous condition ... Dynein is … WebMar 7, 2024 · Dynein is a 1.4 MDa homodimeric complex of two heavy chains, which each binds smaller subunits, including the intermediate …

WebJun 1, 2002 · dynein intermediate chain binding Source:GO_Central. 1 publication. Molecular Function: dynein light intermediate chain binding Source:GO_Central. 1 publication. ... Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. ... WebFeb 5, 2008 · dynein light intermediate chain binding Source:GO_Central. 1 publication. Molecular Function: minus-end-directed microtubule motor activity Source:GO_Central. 1 publication. ... Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. ...

WebSep 7, 2024 · The Hook3 HBS1 region was predicted by running Colabfold 1.2.0 (no templates) on two copies of Hook3 172–287 , one copy of dynein heavy chain 576–864 …

WebMar 21, 2024 · Dynein will initiate translocation of late endosomes to microtubule minus ends only after interacting with betaIII spectrin, which requires the activities of Rab7 … ryan conlon llpWebApr 12, 2024 · Dynein is comprised of six dimeric subunits: heavy chain, intermediate chain, light-intermediate chain, and three distinct light chains. The ATPase motor is contained in the heavy chain and is comprised of six separate ATPase Associated with various cellular Activities (AAA) domains (numbered 1–6), three of which (AAA1, AAA3, … ryan connearney obituary is doxycycline a pcnWebOct 1, 2014 · The LIC domain structure has interesting parallels with the dynein intermediate chain, which has a well-ordered WD repeat domain that interacts with the heavy chain and a less conserved disordered … ryan conlyWebJan 7, 2024 · Schroeder CM, Ostrem J, Hertz NT, Vale RD. A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region. eLife. 2014; 3:e03351. pmid:25272277 ... Mische S, He … ryan connallyWebMay 1, 2001 · The translocation of dynein along microtubules is the basis for a variety of essential cellular movements. Despite a general domain organization that is found in all the cytoskeletal motors, there are structural features of dynein that set it apart from the other motors. These include a track-binding site that is located at the tip of a long projection, … ryan connelly jdhWebFeb 6, 2024 · Previous studies have revealed that all tested cargo adaptors bind two subunits of dynein: the light-intermediate chain and the heavy chain [8. Lee I.-G. et al. ... which they designated the ‘heavy chain-binding site 1’ (HBS1) motif. Interestingly, both BICDR1 molecules in the structure use the HBS1 motif to interact with different dynein-A ... is doxycycline a sulfur drug