Phenylsulfonyl furoxan
WebJan 1, 2024 · Furoxans are an important class of NO donors, which can release high levels of NO in vitro [8]. 3,4-Bis (phenylsulfonyl)-1,2,5-oxadiazole 2-oxide (phenylsulfonylfuroxan), as a NO donor, was widely used in the design of anti-cancer and cancer sensitization agents. WebJan 10, 2024 · Furoxan is the conventional name of 1,2,5-oxadiazole-2-oxide ( Scheme 1a ). It is characterized by an out-of-ring oxygen atom comprising N-oxide, which makes the …
Phenylsulfonyl furoxan
Did you know?
Web3-[(3-Phenylsulfonyl)furoxan-4-yloxy]propan-1-ol C11H12N2O6S CID 44561690 - structure, chemical names, physical and chemical properties, classification, patents, … WebNanoparticles obtained from the coassembly of either 4-(1-(3-methylpentan-5-ol)oxyl)(3-phenylsulfonyl) furoxan (compound 1) or 4-methoxy(3-phenylsulfonyl) furoxan …
WebMar 1, 2024 · In the present study, thirty β-carboline- (phenylsulfonyl)furoxan hybrids (11a−j, 12a−j and 13a−j) were designed and synthesized through esterification and amidation reaction strategy, and their... WebA New Furoxan NO-Donor Rabeprazole Derivative and Related Compounds
WebNov 10, 2016 · Among the furoxan intermediates, only compounds from the phenylsulfonyl (13a-c) series were active against MTB; the MIC 90 for these compounds ranged from 2.89 to 26.01 μM, while the methyl ( 3a-c) and phenyl ( 7a-c) series presented MIC 90 values superior to 88 μM.
WebTherefore, (phenylsulfonyl)furoxan was introduced into the scaffold as a potential NO donor, affording target compounds 9a–9g. Their inhibitory activity against FAK, antiproliferative activity against tumor cells, cellular selectivity, apoptosis-inducing activities, and effects on cell cycle distribution and cell migration were thoroughly ...
WebPhenol 10 was then coupled to 3,4-bis (phenylsulfonyl)furoxan ( 2) in a subsequent step using NaOH and 2-MeTHF to give the desired compound 12a in low yield. Based on this result, we decided to explore derivative 12a synthesis using another route (route B, Scheme 2) by reversing the steps of route A ( Scheme 2 ). dr robey plastic surgery indianaWebirritation skin; nausea, vomiting, abdominal cramps, diarrhea, salivation; headache, dizziness, lassitude (weakness, exhaustion); rhinorrhea (discharge of thin nasal ... collins of abbotsleyWebMar 1, 2024 · In the present study, thirty β-carboline- (phenylsulfonyl)furoxan hybrids (11a−j, 12a−j and 13a−j) were designed and synthesized through esterification and amidation … dr robert young san antonio texasWebA series of novel conjugates of podophyllotoxin and norcantharidin was designed using association strategy, and synthesized by coupling 4 ′-demethylepipodophyllotoxin with N-amino acid norcantharimides, and their cytotoxicitiy was evaluated against four human tumor cell lines (A-549, HepG2, HeLa and HCT-8) and normal human diploid fibroblast line … collins office suppliesWebTo develop multifunctional drugs, a series of celastrol/NO donor hybrids were designed, synthesized and evaluated. The detection of NO release amounts showed that the more NO of these hybrids released, the more tumor cells were inhibited. 11b, which released the highest level of NO in vitro, exhibited superior potency (IC 50 = 0.48 ± 0.06 μM) compared … collins ny real estateWebMay 15, 2024 · In the present study, thirty β-carboline- (phenylsulfonyl)furoxan hybrids (11a-j, 12a-j and 13a-j) were designed and synthesized through esterification and amidation … dr rob forsyth ballaratWebJul 10, 2024 · Furoxan, 1,2,5-oxadiazole N -oxide, is an important scaffold of many compounds that show typical NO-donor properties in mammals, some furoxan derivatives being known as NO-donating pro-drugs [ 23 – 27 ]. dr rob hart calgary