Topcat study spironolactone
Web9. mar 2024 · TOPCAT was a multinational, double-blind, randomized, placebo-controlled, parallel-group study that investigated the effects of the mineralocorticoid receptor antagonist (MRA) spironolactone versus placebo on clinical outcomes in patients with HFpEF. The rationale and design of the study have been previously published (2 or serum … Web8. aug 2024 · Spironolactone has been regarded as a promising medication for the treatment of HFpEF because of its observed positive effects on the cellular, serum biomarker, and echocardiographic level. 10 - 13 In the TOPCAT trial, patients with HFpEF were randomized to spironolactone versus placebo, and no significant difference in the …
Topcat study spironolactone
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Web9. mar 2024 · Spironolactone in Patients With Heart Failure, Preserved Ejection Fraction, and Worsening Renal Function: Published in: Journal of the American College of Cardiology, 77(9), 1211 - 1221. ELSEVIER SCIENCE INC. ISSN 0735-1097. Author Web24. jún 2024 · Spironolactone did not demonstrate benefit with respect to the primary composite endpoint in the global TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist) trial in patients with chronic heart failure with preserved ejection fraction (HFpEF).
WebThe fact that spironolactone significantly reduced the risk of both morbidity and death among the high-risk patients in our study with only a very low incidence of serious hyperkalemia can be ... Web29. mar 2024 · This study randomized patients with HFpEF and either prior hospitalization for HF or elevated NP levels (B-type NP [BNP] ≥100 pg/ml or N-terminal proBNP ≥360 pg/ml) to spironolactone or placebo. Of the 3,445 patients enrolled in the TOPCAT trial, 2,464 (72%) were enrolled in the hospitalization stratum and 981 (28%) in the elevated NP stratum.
WebZurück zum Zitat The CONSENSUS Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure. ... (TOPCAT). Circulation. 2014; ... Zurück zum Zitat Edelmann F, Wachter R, Schmidt AG et al. Effect of Spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction. Web开馆时间:周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆
Web4. apr 2024 · Taken together with other reported regional differences in the TOPCAT trial, the results of the current study arouse concerns regarding study conduct at some sites in Russia and, by implication, Georgia, where event rates and responses to spironolactone were also of concern (Table S3 in the Supplementary Appendix). 2 Our findings suggest that ...
Web27. apr 2024 · In the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial, patients with heart failure and preserved ejection … tsconfig windowWeb9. mar 2024 · TOPCAT was a multinational, double-blind, randomized, placebo-controlled, parallel-group study that investigated the effects of the mineralocorticoid receptor … tsc online advertsWeb10. apr 2014 · Conclusions: In patients with heart failure and a preserved ejection fraction, treatment with spironolactone did not significantly reduce the incidence of the primary … tsconfig workspaceWebTOPCAT Biorepository. Details of the TOPCAT study design and principal results have been previously reported. 1 Briefly, 3445 participants with age ≥50 years, symptomatic HF, left ventricular ejection fraction ≥45%, and either elevated NP (natriuretic peptide) levels or a prior HF hospitalization was randomized to treatment with spironolactone (15– 45 mg … tsconfig webpackWeb1. apr 2024 · Datasets of TOPCAT were obtained from the National Heart, Lung, and Blood Institute according to the application procedure required. Study Population. TOPCAT was a multinational, multicenter, randomized, double-bind, and placebo-controlled trial to assess the efficacy of spironolactone therapy in patients with HFpEF. tsconfig windows 10Web10. jan 2024 · TOPCAT tested spironolactone, a generically available agent, amplifying the potential global public health impact that would come with a favorable finding. However, … tsc online checking statusWebTOPCAT: Spironolactone vs. placebo for the treatment of heart failure with preserved ejection fraction 1 FDA Briefing Document Cardiovascular and Renal Drugs Advisory … tsconfig yaml